Studies on High-Concentration Hydrogen

Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patient with rheumatoid arthritis: an open-label pilot study.

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"We suggest that high H2  water may be useful to complement conventional RA therapy by reducing oxidative stress, especially in early stage and ACPA-negative RA, to assist diagnosis and treatment decisions."

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Ishibashi, T. et al., 2012. Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patient with rheumatoid arthritis: an open-label pilot study. Medical Gas Research, 2: 27

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Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function.

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"Our data suggest that the daily consumption of water containing a high concentration of H2 (over 7 ppm or 3.5 mg in 500 mL of water) may aid in maintaining functional vasculature via two complementary mechanisms. One is neutralization of detrimental ROS to preserve NO bioavailability. The other mechanism is suppression of the inflammatory events that cause atherosclerosis. In light of this and other studies, including the anti-inflammatory effects of H2, we believe that larger-scale clinical research – including biochemical tests – should be conducted to confirm whether H2 can serve as a modulator of the vasomotor function of vasculature and/or can maintain health by constitutively suppressing subclinical inflammation of vasculature."

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Sakai, T. et al., 2014. Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function. Vascular Health and Risk Management: 10: 591-597

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Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases.

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"In conclusion, H2 administration reduced inflammation associated with psoriasis in the three cases examined and it may therefore be considered as a treatment strategy for psoriasis‑associated skin lesions and arthritis."

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Ishibashi, T. et al., 2015. Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases. Molecular Medicine Reports, 12: 2757-2764

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Liu, C., Kurokawa, R., Fujino, M. et al., 2015.  Estimation of the hydrogen concentration in rat tissue using an airtight tube following the administration of hydrogen via various routes. Sci Rep 4, 5485 (2015). https://doi.org/10.1038/srep05485

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Runtuwene J, Amitani H, Amitani M, Asakawa A, Cheng K, Inui A. 2015. Hydrogen–water enhances 5-fluorouracil-induced inhibition of colon cancer. PeerJ 3:e859 https://doi.org/10.7717/peerj.859

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Tan, M., Sun, X., Guo, L., Su, C., Sun, X., & Xu, Z., 2013. Hydrogen as additive of HTK solution fortifies myocardial preservation in grafts with prolonged cold ischemia. International Journal of Cardiology, 167(2), 383–390. doi: 10.1016/j.ijcard.2011.12.109

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